Catching DNA with hoops—biophysical approaches to clarify the mechanism of SMC proteins
نویسندگان
چکیده
منابع مشابه
SMC proteins
What do SMCs do in the cell? Each SMC dimer forms a functional complex with a distinct set of non-SMC subunits. SMC1–3 forms the core of the cohesin complex that functions in sister chromatid cohesion (Figure 1, left). SMC2–4 forms part of the condensin complex, a key player in mitotic chromosome condensation (Figure 1, right). Bacterial SMC is involved in chromosome partitioning and is thought...
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Condensin and cohesin are two protein complexes that act as the central mediators of chromosome condensation and sister chromatid cohesion, respectively. The basic underlying mechanism of action of these complexes remained enigmatic. Direct visualization of condensin and cohesin was expected to provide hints to their mechanisms. They are composed of heterodimers of distinct structural maintenan...
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ژورنال
عنوان ژورنال: Nature Structural & Molecular Biology
سال: 2017
ISSN: 1545-9993,1545-9985
DOI: 10.1038/nsmb.3507